A man took 250,000 steps over the course of a week – here's how his body reacted.
View pictures in App save up to 80% data. Health experts suggest that taking a specific number of steps daily offers numerous advantages (Image: Getty Images). A man who completed 250,000 steps in just a week has shared the effects this challenge had on his physical condition. YouTuber Jack Massey Welsh, aged 28, shared his journey on his channel, where he averaged an impressive 35,700 steps each day. It came with its fair share of difficulties, and he later disclosed that he experienced swollen ankles, sore feet, and a discolored toenail. However, Jack found himself astonished by the transformations in his belly, arms, and legs – a realization that such results could come from simply walking had never crossed his mind. He didn't alter his diet leading up to the challenge, aside from adding more protein in an effort to shed belly fat. Prior to and following the challenge, he took measurements of various body parts, including his torso and legs, to analyze the differences and similarities. On the opening day of the challenge, he remarked: "I feel exhausted, yet I'm okay. It's merely a matter of taking one step at a time." However, those words returned to trouble him on the following day when he admitted, "I was beginning to realize how overly self-assured I had been on the first day. When I boldly stated, ‘It’s simply a matter of putting one foot in front of the other, isn’t it?’ I now see that even that simple act has become quite a challenge," he confessed. "Every single step is painful and feels like a struggle." By the fourth day, although his leg pain had diminished, he began to encounter new physical issues. He mentioned, "At this point, it seems that the only thing holding me back in this challenge is simply the joint pain in my feet." ‘Because even though I in myself have the energy to do 30,000 steps easily today, each step just hurts quite a bit and I am starting to blister up in a few places, so that’s kind of what’s slowing me down.’ By the fifth day, he required pain relief for the blisters, and by the sixth day, he noticed his ankles were swollen. View pictures in App save up to 80% data. After participating in the challenge, Jack observed some changes in his body (Image: YouTube/JackSucksAtLife). In the end, it all paid off, and he remarked: "This was such an incredible sense of achievement. I took a total of 250,000 steps in just one week. For me, the experience itself made it all worthwhile." He also looked at his photos from before and after, remarking, "I appear to be slimmer than I was at the beginning, which took me by surprise. Could this indicate that I've possibly lost some muscle mass?" Jack mentioned that he has shed 2 pounds of belly fat, noting that the difference is visible in his side profile. It was additionally disclosed that the circumference of his arms and torso had decreased slightly, while his thighs had increased by 0.5cm. View pictures in App save up to 80% data. First look at UK's £12,000,000,000 next generation combat aircraft programme Father 'stabbed daughter to death while play-fighting in kitchen', court hears Neighbours woken by 'horrific screams' after man stabbed to death on estate The main inquiry is whether he would undertake the challenge once more, and he disclosed: 'Would I suggest taking 250,000 steps in a week? Definitely not.' "My joints just couldn't handle it; even two days later, I'm still hoping the swelling around my ankles will go down." Research indicates that for individuals over 60, taking 6,000 steps daily can reduce the risk of premature death by 50%, while exceeding 8,000 steps does not provide significant additional advantages. The concept of walking 10,000 steps daily originated as a marketing strategy by a Japanese company that aimed to promote pedometers following the 1964 Tokyo Olympics.
Adial Pharmaceuticals: A Conversation with Cary Claiborne Regarding the Addiction Treatment Firm
Adial Pharmaceuticals is a biopharmaceutical firm in the clinical development phase, dedicated to creating therapies for addiction disorders. In an exclusive interview with Pulse 2.0, CEO and board member Cary Claiborne Sr. shared insights about the company's mission and progress. Cary Claiborne’s History View pictures in App save up to 80% data. Cary Claiborne has a diverse background that spans various fields. He has experience in both the corporate world and community service, which has shaped his perspective and approach to leadership. Claiborne mentioned that his journey has been influenced by his commitment to making a positive impact in his community and his dedication to professional excellence. "I started my professional journey at GE while pursuing an MBA from Villanova University. I progressed through various roles, beginning in GE's Financial Management Program and ultimately attaining the role of President of New Enterprise Wholesale Services. After that, I took on numerous positions in diverse sectors, including roles at Home Depot and MCI." "Having dedicated two decades to non-healthcare industries, I discovered my true passion lay in collaborating with organizations committed to creating therapies that address the unmet needs of patients. Consequently, I have held leadership roles in various biotech and biopharma firms, such as Osiris Therapeutics, Sucampo Pharmaceuticals, and Indivior. During my tenure as CFO at Indivior, I concentrated on initiatives aimed at making a difference for patients grappling with addiction. This commitment inspired my transition to Adial Pharmaceuticals, where I became a board member in 2021, assumed the role of COO later that year, and was appointed CEO in August 2022." Creation of Adial What inspired the formation of the company? Claiborne revealed: "The creators of Adial understood the pressing necessity to create effective solutions for the millions affected by alcohol use disorder, who are searching for treatments that align with their individual paths to recovery." "We dedicated ourselves to thoroughly reviewing the scientific literature and crafting a strategy grounded in the fundamental science. Our approach centers on targeting serotonin signaling to interfere with the neural pathways associated with alcohol addiction. Additionally, we assessed current trends and research in addiction treatment, particularly the impact of harm reduction in supporting individuals during their recovery journey. This exploration inspired us to pursue an innovative idea: creating a therapy for alcohol use disorder that does not rely on complete abstinence." Cherished Moment Claiborne reminisced about a particularly memorable moment during their time with the company, saying: “Reviewing the detailed analysis of the Phase 3 ONWARD trial results by each of the four Genotypes that were enrolled in the trial and learning that one of those four Genotypes (AG) significantly outperformed the others in terms of their response to AD04. Then going backwards to even our prior Phase 2 data to confirm that the AG signal wasn’t just some anomaly, and finding the same result was a great memory. What that meant was that there was a clear path forward in future trials if we focused initially on that genotype. The key is developing a plan after you’ve gotten trial results, seeing where the successes are, and then formulating a strategy to move to the next stage. That moment became the foundation for where we are going as a company now.” Essential Offerings What are the main products and features of the company? Claiborne elaborated: “Our primary asset is AD04, a genetically targeted antagonist of the serotonin-3 receptor designed to treat Alcohol Use Disorder. This innovative mechanism sets it apart from current treatment options for Alcohol Use Disorder, and we believe it could work synergistically with existing therapies. We have pinpointed particular genetic groups that are likely to benefit the most from this treatment and are currently working on a companion diagnostic test to help identify these patients.” Obstacles Encountered What obstacles has Claiborne and the team encountered while establishing the company? Claiborne admitted: “Recent economic changes following the peak in biotech funding a few years ago, and subsequent downturn in the years after have posed significant challenges for the industry as a whole. Investors tend to be cautious to deploy capital in uncertain economic times, and biotech companies are inherently risky due to the lengthy and costly process of bringing a new therapy to market. To overcome this challenge, we have had to be innovative in our approach to fundraising. We also took this opportunity to focus on demonstrating the robustness of our scientific data and recently published several peer-reviewed studies highlighting the safety and utility of our approach.” "The stigma associated with addiction continues to pose a major obstacle. Many people misinterpret addiction as a personal shortcoming instead of recognizing it as a multifaceted medical issue that necessitates professional care. In response to this challenge, we have emphasized the importance of education and advocacy within our overall approach." The Progression of Adial's Technology How has the company’s technology progressed since its inception? Claiborne mentioned: “As we’ve gained a more comprehensive understanding of the complex nature of addiction, we’ve managed to narrow our focus down to specific genotypes that respond more positively to our therapy. Not everyone responds the same way to certain medications, so we have really focused on pinpointing a subset of patients with alcohol use disorder in whom AD04 is predicted to elicit a particularly robust response and are now using a genetic diagnostic assay to detect these individuals on a genetic basis.” Notable Achievements What are some of the most notable milestones achieved by the company? Claiborne mentioned: “Drawing from the solid data obtained in our Phase 2b and 3 clinical trials, we successfully conducted a fruitful meeting with the FDA. In this discussion, we were pleased to receive positive feedback regarding our current data as well as our strategic plans for the future. The insights provided by the FDA were instrumental in shaping a thorough regulatory strategy for our next actions. These conversations marked an important milestone for our organization, offering not just a clear direction ahead, but also a vital synchronization of our company’s goals and priorities. This alignment will empower us to maneuver through the regulatory environment with greater efficiency and propel AD04 forward with assurance.” Standing Out From The Competition What sets the company apart from its competitors? Claiborne stated: “What sets us apart from others in the Alcohol Use Disorder treatment space is the use of personalized medicine and our non-abstinence-based approach. By using precision medicine to identify the patients most likely to benefit from our therapy, we believe we are placing ourselves on the razor’s edge of scientific advancements in modern medicine. Addiction is a complicated disorder with lots of different causal factors, and everyone’s path to recovery is different. By focusing on a specific population of patients and giving them a pharmacological therapy that offers a flexible path to recovery, we believe we are really doing something groundbreaking compared to what has long been the status quo.” "Our choice to adopt a non-abstinence-based approach to addiction treatment is founded on the principle of harm reduction, which is supported by extensive research in the field. In contrast to conventional methods that require total abstinence, our strategy recognizes the intricate nature of addiction and the diverse journeys toward recovery. By concentrating on minimizing harmful behaviors and enhancing overall well-being, we provide a more empathetic and pragmatic option for individuals who find the strictness of abstinence-only programs challenging. This approach is especially advantageous for patients who may not be prepared or able to fully abstain but are eager to decrease their substance use and mitigate its adverse effects." Aspirations for Our Company’s Future What are some of the company's future objectives? Claiborne summarized: “Our immediate objective is to launch our scheduled Phase 3 clinical trial for AD04. Achieving this milestone is vital, as it will enable us to gather the essential data needed to prove the safety and effectiveness of AD04 in addressing alcohol use disorder.” "Our primary goal is to deliver an effective therapy to individuals who need it the most, providing hope for those battling alcohol use disorder. While we are making progress in developing AD04, we are also establishing a foundation for its ability to revolutionize addiction treatment."
Uncover the Distinctive Sandwich of King Charles: Nutritious Components & Regal Taste
View pictures in App save up to 80% data. King Charles' unique sandwich presents a delightful combination of tastes and nutritional advantages, encouraging you to discover the creativity of royal cuisine. This mouthwatering creation transcends the traditional sandwich; it marks a transformation in our perception of royal dining. King Charles demonstrates his culinary skills by blending various ingredients that align with health-conscious trends. As individuals become more attentive to their dietary selections, a dish that marries flavor with wellness becomes an appealing offer. This intriguing fusion sparks a culinary adventure that inspires people to broaden their culinary horizons beyond the usual bread options. The essence of Charles' sandwich lies in its dedication to organic ingredients. This trend celebrates the benefits of natural components, highlighting how delectable and nutritious food can please even the most selective taste buds. Organic produce not only promotes well-being but also fosters sustainability, catering to the increasing desire for eco-friendly practices. Conscious eating choices strike a chord with modern consumers, positioning organic options as a profitable movement. Health-focused people are increasingly drawn to meals that emphasize nutritious ingredients. Foods rich in vitamins, minerals, and antioxidants not only support general health but also delight the palate. The sandwich favored by King Charles serves as a perfect example, featuring fresh, organic vegetables and carefully selected proteins. This approach aligns perfectly with modern dietary trends, offering a tasty option for anyone looking to sustain a healthy lifestyle. Incorporating Marmite into King Charles' sandwich enhances its taste and highlights the cultural importance of local spreads within British gastronomy. This renowned yeast extract has a mix of ardent supporters and critics, yet its inclusion represents a cherished tradition among the British populace. The umami flavor it introduces adds an intriguing element, demonstrating how classic ingredients can be innovatively adapted for contemporary palates. This approach appeals to those who enjoy culinary exploration, proving that experimenting with flavors can yield unexpectedly delightful results. Royal gastronomy typically represents the pinnacle of fine dining, but King Charles is reshaping it to be more inclusive. By championing inventive culinary exploration, he inspires individuals beyond the confines of royal kitchens to try new things with their meals. This spirit of innovation in the culinary world enhances the dining experience and fosters a sense of community among those who appreciate the art of cooking. Looking at the bigger picture, the incorporation of diverse ingredients highlights a significant movement within the culinary world. More and more diners are on the lookout for experiences that transcend traditional dining, preferring meals that narrate stories and embody cultural traditions. King Charles’ sandwich embodies this ethos, welcoming all to enjoy a dish that links them to the vibrant history of British cuisine. This trend inspires restaurants and food innovators to delve into a broader range of culinary adventures, creating opportunities for a more varied menu selection. As you explore the world of cooking, think about how King Charles' philosophy can influence your own culinary experiences. Embracing experimentation allows you to uncover exciting flavors and innovative pairings. This royal mindset honors the artistry of food, encouraging everyone to forge a stronger connection with their culinary heritage while broadening their palate. In a landscape filled with quick-service dining choices, dedicating time to crafting nutritious, homemade meals emerges as a vital endeavor. King Charles’ distinctive sandwich champions this idea by emphasizing the significance of prioritizing quality over mere quantity in our dietary selections. Utilizing whole, organic ingredients in meal preparation not only enhances health but also cultivates a greater appreciation for the culinary arts. Furthermore, this emphasis on a variety of flavors and fresh ingredients resonates strongly with the growing interest in sustainable and ethical eating habits. For consumers, being mindful of trends and opting for locally sourced produce while supporting ethical brands can significantly benefit both individual health and the wider community. The relationship between our food choices and their environmental effects is more evident than ever, highlighting the importance of making decisions that align with our values. As you explore the realm of culinary creativity influenced by King Charles, think about ways to incorporate these strategies into your own meals. A thoughtfully crafted sandwich can transform into your own culinary work of art, igniting engaging conversations with friends and family. By sharing distinctive, flavor-rich sandwiches, you can inspire discussions about nutrition, sourcing ingredients, and cultural importance, thereby strengthening bonds and creating unforgettable dining moments. In the end, King Charles’ groundbreaking sandwich serves not just as a delightful snack but also represents a dedication to health, sustainability, and inventive cooking. Exploring these concepts can elevate your dining experience and prompt a thorough reconsideration of what we deem a satisfying and healthful dish. Embrace the trends that align with your individual path and savor the tastes that showcase the lively diversity of British culinary traditions.
Unlocking the Secrets to Flavoring Rice in Your Rice Cooker
View pictures in App save up to 80% data. Lesterman/Shutterstock.com Cooking rice on the stove can be effective, but let's face it: using a rice cooker makes everything simpler. By removing the constant need to stir and the worry of burning the bottom, the whole process becomes much more pleasant and stress-free. All it takes is adding rice and water to the cooker, pressing a button, and fluffing the rice when it's finished—it's really that easy. This handy kitchen device also simplifies the task of adding flavor to your food. Just remember to put your seasonings in the rice cooker at the beginning of the cooking process, allowing the grains plenty of time to absorb all those delicious flavors. Whether you use broth, butter, dried herbs, or olive oil, you'll notice a major difference when you incorporate them before the food has been cooked as opposed to after. Even Gordon Ramsay agrees and abides by this rule when seasoning rice; if you wait until it's fully cooked, your flavors won't blend completely into the grains, which will make for an unimpressive result. Whatever you decide to season it with — even if it's just a bit of salt and pepper — simply add it before you begin the rice cycle, and cook the rice as usual. Top Methods for Pre-Seasoning Your Rice View pictures in App save up to 80% data. Nata_vkusidey/ Getty Images The type of rice you select will also affect the outcome. It's better to choose a long-grain variety, like jasmine or basmati. They're less likely to get soggy after seasonings are added to them. You could also use brown rice, but be aware that it cooks slower than white rice because of its bran layer, which means it takes longer to absorb water. Considering the right seasonings to enhance your dish is crucial. One easy method to infuse flavor into white rice is by placing a bay leaf in the rice cooker. While the taste is mild, it enriches the overall flavor profile. Additionally, incorporating whole cardamom pods can further elevate the taste of your rice. If cardamom and bay leaves are too subtle for your liking, feel free to get a little adventurous with the seasoning. Before you begin the rice cycle, try throwing in some garlic powder, onion powder, thyme, and parsley, making sure it all gets well-incorporated in the water-rice mixture. We also like using chopped up, fresh herbs, like rosemary, dill, and basil. If you want to really give your rice a flavor boost, use a chicken or vegetable broth instead of water. This is the easiest way to add extra flavor to your rice even when you're short on fresh herbs.
Rod Stewart experienced a chilling moment of fear after receiving a shocking health diagnosis that left his palms feeling icy.
Rod Stewart received the shocking diagnosis of thyroid cancer during a routine check-up at the doctor's office, leading him to undergo surgery. View pictures in App save up to 80% data. Rod Stewart has been given a frightening diagnosis of cancer. Rod Stewart has shared a chilling account of a health scare that left him feeling "fearful" and "vulnerable." In his 2012 memoir, Rod: The Autobiography, the Maggie May crooner detailed how a routine check-up at Cedars-Sinai Medical Center in Los Angeles took a terrifying turn. Despite feeling as "fit as a butcher's dog," Rod was called into the doctor's office after tests revealed an anomaly on his thyroid gland. Rod penned: "The following day, I went back to the hospital and underwent a biopsy. Under a local anesthetic, part of the affected area was removed using a needle and taken away for analysis." A phone call the next day delivered the chilling news: "The results of the tests indicated that the 'something' on my thyroid gland was a malignant growth: cancer." Rod admitted that hearing this kind of news can be quite unsettling, revealing that he felt more "fearful" and "vulnerable" than ever in his life. View pictures in App save up to 80% data. He expressed a sense of being exposed and defenseless. Just two days later, he was back in the hospital for surgery, checking in under the pseudonym "Billy Potts" - a nod to his dogs' names - to dodge the media. He disclosed that the four-hour operation brought the surgeon's knife perilously close to his vocal cords, meaning "any slip" could have ended his singing career, reports the Daily Record. The procedure went well, and the legendary vocalist avoided chemotherapy, ensuring that his trademark hairstyle remained intact. Displaying his usual sense of humor, he quipped that going bald would pose a career-threatening dilemma "second only" to the loss of his singing ability. In a 2021 episode of the UK talk show Loose Women, Rod revealed that he had faced issues with voice loss. He acknowledged that the carefree days of partying all night, drinking, and living wildly without consequences for his voice are behind him, and that he now needs to take measures to "protect" it. Looking back on his health scare, he remarked: "I experienced a brief episode of thyroid cancer, but it was resolved in just 10 minutes. I don't want to give the impression that I battled cancer for an extended period. It was quite straightforward to eliminate, though I did completely lose my voice." Subscribe to our FREE newsletter and receive the latest headlines directly in your inbox! DAILY NEWSLETTER: Sign up here to get the latest news and updates from the Mirror US straight to your inbox with our FREE newsletter.
HEALTH FOCUS: Approaches to Managing Menopause
View pictures in App save up to 80% data. Every day, statistics indicate that approximately six thousand women experience menopause. Dr. Shayla Toombs-Withers from the Essence of Health Wellness Clinic notes, “Many women may begin to experience symptoms in their late 30s or 40s without realizing what is happening.” That is until they come to the shocking realization that a whole year has passed without a menstrual cycle. According to Dr. Toombs-Withers, some of the most frequently observed symptoms include: Hot flashes Difficulty sleeping Mood changes Brain fog According to Dr. Shayla Toombs-Withers, "Consuming a high amount of processed and fried foods can exacerbate those symptoms and lead to a woman feeling even more unwell." Verses eating more plant-based foods. When it comes to treatment, most women turn to hormone therapy, but Dr. Toombs-Withers says patients should consider other options like herbal medicine, nutrition, physical activity, and mental well-being. Dr. Shayla Toombs-Withers says, “I always tell women to check with your doctor and make sure those things are safe for you. But there are alternatives to hormone therapy.” Dr. Shayla Toombs-Withers says, “It really depends on the individual. Some are ready for the change, and they will do those things.” Consistency is key. Dr. Toombs-Withers says whichever option you choose, it usually takes several months to see results. Dr. Shayla Toombs-Withers says, “The key thing I would like women to know is you don’t have to suffer in silence or feel like you have to deal with it. There are solutions that can help.” The duration of menopause can range from two to eight years. For more information, click here.